Identifying Novel Genetic & Epigenetic Cancer Markers, Investigating Their Roles in Tumorigenesis

A private institution established in 2013 with research programs in cancer, neuroscience, genomics, and bioinformatics, and with a broad educational mission.

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ABOUT OUR RESEARCH

The JS Yoon Memorial Cancer Research Institute was founded in 2013 by Dr. Chulso Moon in memory of his mother, Dr. JS Yoon, who passed away from cancer. JS Yoon Memorial Cancer Research Institute is an independent research laboratory located in the University of Maryland BioPark. It is dedicated to furthering our understanding of the genetic and epigenetic bases of cancer and to translating this knowledge into novel diagnostics and therapeutics. Our expertise is in identifying novel genetic and epigenetic cancer markers and in investigating their roles in tumorigenesis.

 EMPLOYMENT - Current Openings
Post-doctoral Fellow in Immunology: A postdoctoral fellow position is open to study the functions and mechanisms of Treg cells in cancer and autoimmune diseases using mouse models. The ideal candidate will be a recent graduate within the last three years of obtaining a Ph.D. in immunology or a related field. Experience with tissue culture, procedures on mice, and standard molecular biology methodologies are desired. Excellent verbal and written skills in English are required.

Post-doctoral Fellow in Neuroscience: A postdoctoral fellow position is open to study various neurodegenerative and developmental disorders in mouse models. The ideal candidate will be a recent graduate within the last three years of obtaining a Ph.D. in neuroscience or a related field. Experience with tissue culture, procedures on mice, and standard molecular biology methodologies are desired. Excellent verbal and written skills in English are required.

Lab Manager: All interested and qualified candidates are encouraged to apply.
Responsibilities:
• Manages the day-to-day operations with Lab Staffs & Interns.
• Assists in managing the platform Lab/Research budget. 
• Maintains reports of experimental data and protocols.
• Update Daily, Weekly & Monthly Reports in the System.
• Develop and enforce lab standard policy & procedures.
• Coordinate for Meetings & Conference as per management request. 
• Perform other related duties as assigned.
Education: Required: Masters / Bachelor's degree in Science. Must have excellent organizational, written and verbal communications skills, the ability to complete assignments on schedule, problem solving, managing for results, organizing, prioritizing and to adjust to changing situations and work assignments.

CONTACT FOR ALL POSITIONS:  jobs@jsyresearch.org

OUR STAFF

Chulso Moon, M.D., Ph.D.-President


Dr. Chulso Moon is the founder and President of the JS Yoon Memorial Cancer Research Institute. Dr. Moon earned his Ph.D. in Human Genetics and Molecular Biology from The Johns Hopkins University School of Medicine where his doctoral work included the cloning of the human gene for AQP1, a unique water channel molecule, under the mentorship of the Nobel Laureate Dr. Peter Agre. He received his M.D. from Seoul National University School of Medicine and completed his post-doctoral training at the MD Anderson Cancer Center.

 
Annie John – Managing Director

Annie John joined the JS Yoon Memorial Cancer Research Institute as General Manager since its inception in March 2013. She obtained her Bachelor of Arts in English Language & Literature and Masters in Sociology. Annie also possesses diplomas in Event Management, Public Relations & Advertising, and Practical Nursing. Before joining JSY, Annie was the Administrator- in-Charge and Human Resource Specialist of a high profile Middle Eastern organization for over six years. She has also proved her versatile capabilities in the regional media industry in Dubai and the U.S.

 

 

PUBLICATIONS

List of Select Publications

Agre P, Preston GM, Smith BL, Jung JS, Raina S, et al. (1993) Aquaporin CHIP: the archetypal molecular water channel. Am J Physiol 265: F463–476. (link)

Moon C, Preston GM, Griffin CA, Jabs EW, Agre P (1993) The human aquaporin-CHIP gene. Structure, organization, and chromosomal localization. J Biol Chem 268: 15772–15778. (link)

Moon C, Williams JB, Preston GM, Copeland NG, Gilbert DJ, et al. (1995) The mouse aquaporin-1 gene. Genomics 30: 354–357. doi:10.1006/geno.1995.0029. (link)

Moon C, King LS, Agre P (1997) Aqp1 expression in erythroleukemia cells: genetic regulation of glucocorticoid and chemical induction. Am J Physiol 273: C1562–1570. (link)

Soria JC, Moon C, Wang L, Hittelman WN, Jang SJ, et al. (2001) Effects of N-(4-hydroxyphenyl)retinamide on hTERT expression in the bronchial epithelium of cigarette smokers. J Natl Cancer Inst 93: 1257–1263. (link)

Moon C, Oh Y, Roth JA (2003) Current status of gene therapy for lung cancer and head and neck cancer. Clin Cancer Res 9: 5055–5067. (link)

Moon C, Soria J-C, Jang SJ, Lee J, Obaidul Hoque M, et al. (2003) Involvement of aquaporins in colorectal carcinogenesis. Oncogene 22: 6699–6703. (link)

Soria J-C, Moon C, Kemp BL, Liu DD, Feng L, et al. (2003) Lack of interleukin-10 expression could predict poor outcome in patients with stage I non-small cell lung cancer. Clin Cancer Res 9: 1785–1791. (link)

Goldenberg D, Lee J, Koch WM, Kim MM, Trink B, et al. (2004) Habitual risk factors for head and neck cancer. Otolaryngol Head Neck Surg 131: 986–993. (link)

Moon C, Rousseau R, Soria J-C, Hoque MO, Lee J, et al. (2004) Aquaporin expression in human lymphocytes and dendritic cells. Am J Hematol 75: 128–133. (link)

Topaloglu O, Hoque MO, Tokumaru Y, Lee J, Ratovitski E, et al. (2004) Detection of promoter hypermethylation of multiple genes in the tumor and bronchoalveolar lavage of patients with lung cancer. Clin Cancer Res 10: 2284–2288. (link)

Hoque MO, Soria J-C, Woo J, Lee T, Lee J, et al. (2006) Aquaporin 1 is overexpressed in lung cancer and stimulates NIH-3T3 cell proliferation and anchorage-independent growth. Am J Pathol 168: 1345–1353. (link)

Chae YK, Kang SK, Kim MS, Woo J, Lee J, et al. (2008) Human AQP5 plays a role in the progression of chronic myelogenous leukemia (CML). PLoS ONE 3: e2594. (link)

Chae YK, Woo J, Kim M-J, Kang SK, Kim MS, et al. (2008) Expression of aquaporin 5 (AQP5) promotes tumor invasion in human non small cell lung cancer. PLoS ONE 3: e2162. (link)

Kang SK, Chae YK, Woo J, Kim MS, Park JC, et al. (2008) Role of human aquaporin 5 in colorectal carcinogenesis. Am J Pathol 173: 518–525. (link)

Liu J-W, Nagpal JK, Jeronimo C, Lee JE, Henrique R, et al. (2008) Hypermethylation of MCAM gene is associated with advanced tumor stage in prostate cancer. Prostate 68: 418–426. (link)

Liu J-W, Nagpal JK, Sun W, Lee J, Kim MS, et al. (2008) ssDNA-binding protein 2 is frequently hypermethylated and suppresses cell growth in human prostate cancer. Clin Cancer Res 14: 3754–3760. (link)

Moon C, Park JC, Chae YK, Yun JH, Kim S (2008) Current status of experimental therapeutics for prostate cancer. Cancer Lett 266: 116–134. (link)

Moon C-S, Agbo EC, Sidransky D (2008) Slow development impedes the uptake of diagnostics. Nature 451: 16. (link)

Park JC, Chae YK, Son CH, Kim MS, Lee J, et al. (2008) Epigenetic silencing of human T (brachyury homologue) gene in non-small-cell lung cancer. Biochem Biophys Res Commun 365: 221–226. (link)

Woo J, Chae YK, Jang SJ, Kim MS, Baek JH, et al. (2008) Membrane trafficking of AQP5 and cAMP dependent phosphorylation in bronchial epithelium. Biochem Biophys Res Commun 366: 321–327. (link)

Woo J, Lee J, Chae YK, Kim MS, Baek JH, et al. (2008) Overexpression of AQP5, a putative oncogene, promotes cell growth and transformation. Cancer Lett 264: 54–62. (link)

Woo J, Lee J, Kim MS, Jang SJ, Sidransky D, et al. (2008) The effect of aquaporin 5 overexpression on the Ras signaling pathway. Biochem Biophys Res Commun 367: 291–298. (link)

Lee J, Jang SJ, Benoit N, Hoque MO, Califano JA, et al. (2010) Presence of 5-methylcytosine in CpNpG trinucleotides in the human genome. Genomics 96: 67–72. (link)

Moon C, Chae YK, Lee J (2010) Targeting epidermal growth factor receptor in head and neck cancer: lessons learned from cetuximab. Exp Biol Med (Maywood) 235: 907–920. (link)

Lee J, Moon C (2011) Current status of experimental therapeutics for head and neck cancer. Exp Biol Med (Maywood) 236: 375–389. (link)

 

 

CONTACT INFO

OFFICE 

JS Yoon Memorial Cancer Research Institute
801 West Baltimore Street, Suite 502-K,
Baltimore, MD 21201

LABORATORY

JS Yoon Memorial Cancer Research Institute
801 West Baltimore Street, Suite 502-I,
Baltimore, MD 21201
phone: 410.332.9940
email: info@jsyresearch.org